Journal article
Association between malaria immunity and pregnancy outcomes among Malawian pregnant women receiving nutrient supplementation
UP Chandrasiri, FJI Fowkes, JG Beeson, JS Richards, S Kamiza, K Maleta, P Ashorn, SJ Rogerson
Malaria Journal | BMC | Published : 2016
Abstract
Background: Malaria antibody responses measured at delivery have been associated with protection from maternal anaemia and low birth weight deliveries. Whether malarial antibodies present in the first half of pregnancy may protect from these or other poor birth outcomes is unclear. To determine whether malaria antibodies in the first half of pregnancy predict pregnancy outcomes, antibodies were measured to a range of merozoite antigens and to antigens expressed on the surface of parasitized red blood cells (pRBCs) in plasma samples collected at 14-20 weeks of gestation from Malawian women. The latter antibodies were measured as total IgG to pRBCs, and antibodies promoting opsonic phagocytosi..
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Grants
Awarded by United States Agency for International Development
Funding Acknowledgements
This publication is based on research funded in part by a grant from the Office of Health, Infectious Diseases, and Nutrition, Bureau for Global Health, U.S. Agency for International Development (USAID) under terms of Cooperative Agreement No. AID-OAA-A-12-00005, through the Food and Nutrition Technical Assistance III Project (FANTA), managed by FHI 360. Additional funding was obtained from a grant to the University of California, Davis from the Bill & Melinda Gates Foundation and the Academy of Finland. SJR is supported by the National Health and Medical Research Council (NHMRC) of Australia. JGB supported by a Senior Research Fellowship by the NHMRC of Australia. The Burnet Institute is supported by the NHMRC IRIIS Scheme and Victorian State Government Operational Infrastructure Support.